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    • 专利摘要:
    "DRUG DELIVERY DEVICE". The invention relates to a reusable drug delivery device (1) for selecting and dispensing a number of varying doses of a drug user. The device (1) comprises a housing (10, 20), a cartridge holder (80) for holding a cartridge (81) containing the medication, a piston rod (30) displaceable with respect to the cartridge holder (80), a driver (40) coupled to the piston rod (30), a display element (60) to indicate an established dose and being coupled to the housing (10, 20) and the driver (40), and a button (70) coupled the display element (60) and the driver (40).
    公开号:BR112015004132B1
    申请号:R112015004132-9
    申请日:2013-08-29
    公开日:2021-02-23
    发明作者:David Aubrey Plumptre；Thomas Frederick Osman
    申请人:Sanofi-Aventis Deutschland Gmbh；
    IPC主号:
    专利说明:

    [001] The present invention in general relates to drug delivery devices. More particularly, the present invention relates to reusable drug delivery devices.
    [002] Drug delivery devices such as thermo-application pen where regular injection occurs by people without formal medical training. This can be increasingly common among patients with diabetes where self-treatment enables such patients to conduct effective management of their disease. In practice, a drug delivery device like this allows a user to individually select and dispense a number of varying doses of a drug user. The present invention is not directed to so-called fixed dose devices that only allow dispensing a predefined dose without the possibility of increasing or decreasing the established dose.
    [003] There are basically two types of drug delivery devices: devices capable of being restored (ie, reusable) and not capable of being restored (ie, disposable). For example, disposable pen delivery devices are provided as stand-alone devices. Such standalone devices do not have removable pre-filled cartridges. Preferably, pre-filled cartridges cannot be removed and replaced in these devices without destroying the device itself. Consequently, such disposable devices do not need to have a dose adjustment mechanism capable of being restored.
    [004] These types of pen-type delivery devices (named because they often look like an enlarged-source pen) are generally comprised of three primary elements: a cartridge section that includes a cartridge often contained within a housing or support; a needle assembly connected to one end of the cartridge section; and a dosing section connected to the other end of the cartridge section. A cartridge (often referred to as an ampoule) typically includes a reservoir that is filled with a medication (for example, insulin), a mobile-type rubber stopper or plug located at one end of the cartridge reservoir, and a top having a seal perforated rubber located at the other end, often with a reduced neck. Crumpled annular metal tape is typically used to hold the rubber seal in place. While the cartridge housing can typically be made of plastic, cartridge shells have historically been made of glass.
    [005] The needle assembly is typically a replaceable double-ended needle assembly. Before an injection, a replaceable double-ended needle assembly is attached to one end of the cartridge assembly, a dose is established, and then the established dose is administered. Such removable needle assemblies can be threaded, or pushed (i.e., engaged), into the piercable sealing end of the cartridge assembly.
    [006] The dosing section or dose setting mechanism is typically the part of the pen device that is used to establish a dose. During an injection, a piston shaft or rod contained within the dose setting mechanism presses against the cartridge stopper or plug. This force causes the medication contained in the cartridge to be injected through a fixed needle assembly. After an injection, as generally recommended by many manufacturers and suppliers of drug delivery devices and / or needle assemblies, the needle assembly is removed and discarded.
    [007] For reusable drug delivery devices, it is necessary to allow the piston rod or lead screw to be reinstated, that is, pushed and / or rotated back into the device, during the step of replacing an empty cartridge with a cartridge new (full). In addition, many drug delivery devices comprise a dose limiter to prevent the establishment of a dose that exceeds the amount of liquid left in a drug delivery device cartridge. If a dose limiter like this is provided, this dose limiting mechanism must also be reinstated.
    [008] In the following, the restoration of the device is intended to understand the procedure of replacing or replacing a cartridge that involves a retraction of the piston rod or lead screw and, if present, take the dose limiter (last-dose protection mechanism). ) back to an initial setting allowing dose restoration.
    [009] It is an object of the present invention to provide an improved reusable drug delivery device.
    [0010] In accordance with a first embodiment of the present invention, this objective is achieved by means of a drug delivery device for selecting and dispensing a number of variable doses of a drug user, comprising a housing, a cartridge holder for retain a cartridge containing the medication, a piston rod displaceable in relation to the cartridge holder, a trigger coupled to the piston rod, a display element to indicate an established dose and being coupled to the housing and the trigger, a coupling to rotate coupling the actuator to the housing or the display element and a button rotatably coupled to the display element and the actuator, in which the actuator is threaded with the piston rod, permanently rotated to the button, which can be axially displaced in relation to the button and comprises at least two separate components that are rotatably coupled during dose setting and during dis dose compensation and that are rotated uncoupled during device restoration. Uncoupling the two driver components during reset has the benefit that both the piston rod, which is threaded into the driver, and a dose-limiting mechanism, which usually acts on the driver, can be reset together by rotating one of the driver components while the other remains stationary in the device. The driver can comprise a third component for coupling the first and second components during dose setting and dose dispensing.
    [0011] In accordance with a second embodiment of the present invention, this objective is achieved by means of a drug delivery device for selecting and dispensing a number of variable doses of a drug user, comprising a housing, a cartridge holder for retain a cartridge containing the medication, a piston rod displaceable in relation to the cartridge holder, a trigger coupled to the piston rod, a display element to indicate an established dose and being coupled to the housing and the trigger, a coupling to rotate coupling the actuator to the housing or the display element and a button rotatably coupled to the display element and the actuator, where the display element has a distal end provided with a thread extending internally and a proximal end provided with a flange extending internally , wherein the display element comprises two separate components with a first component comprising the thread and the other component comprising the flange. The display element must be coupled to the housing and the driver. The construction of the display element with two inward-facing snap-in features avoids a bulky design of the device that would result if one snap-in feature were on the outside and the other was on the inside of the display. In addition, the inwardly directed snap-in features make it possible to provide additional functions on the outer surface of the display element, for example, limiting stop elements. Providing two separate components, which are preferably axially and rotationally constrained, makes production of the display element more efficient and easier. Preferably, the display element has a series of numbers or similar symbols arranged on its outer surface to indicate an established dose. If the display element is threaded with the housing, the numbers or the like can be arranged on a helical path.
    [0012] In accordance with a third embodiment of the present invention, this objective is achieved by means of a drug delivery device for selecting and dispensing a number of variable doses of a drug user, comprising a housing, a cartridge holder for retain a cartridge containing the medication, a piston rod displaceable in relation to the cartridge holder, a trigger coupled to the piston rod, a display element to indicate an established dose and being coupled to the housing and the trigger, a coupling to rotate coupling the actuator to the housing or the display element and a button rotatably coupled to the display element and the actuator, wherein the button comprises fingers that engage with corresponding grooves of the actuator to rotatively engage the button to the actuator and which comprise interlocking features that engage with corresponding fitting features of the coupling to axially couple the button to the coupling. In other words, the actuator and the button are rotatably coupled by a tooth coupling or claw coupling with the fingers of the button having the additional function of axially restricting the button in relation to the coupling element. This additional function in a component reduces the number of component parts of the device and assembly complexity.
    [0013] In accordance with a fourth embodiment of the present invention, this objective is achieved by means of a drug delivery device for selecting and dispensing a number of variable doses of a drug user, comprising a housing, a cartridge holder for retain a cartridge containing the medication, a piston rod displaceable in relation to the cartridge holder, a trigger coupled to the piston rod, a display element to indicate an established dose and being coupled to the housing and the trigger, a coupling to rotate coupling the actuator to the housing or the display element and a button rotatably coupled to the display element and to the actuator, wherein the actuator comprises fingers that engage with corresponding slots of the button to rotatively engage the button to the actuator and which comprise features of hooks that fit with corresponding contact features of the display element to axially couple the actuator to it display equipment. In other words, the actuator and the button are rotatably coupled by a tooth coupling or claw coupling with the fingers of the actuator having the additional function of axially engaging with the display element, for example, when dragging the display element during dispensing dose. This additional function in a component reduces the number of component parts of the device and assembly complexity.
    [0014] In accordance with a fifth embodiment of the present invention, this objective is achieved by means of a drug delivery device for selecting and dispensing a number of variable doses of a drug user, comprising a housing, a cartridge holder for retain a cartridge containing the medication, a piston rod displaceable in relation to the cartridge holder, a trigger coupled to the piston rod, a display element to indicate an established dose and being coupled to the housing and the trigger, a coupling to rotate coupling the actuator to the housing or the display element and a button rotatably coupled to the display element and the actuator, wherein the button comprises a ring of clicker teeth that fits with a corresponding clicker feature of the display element at least during dispensing of dose. The clicker produces a tactile and / or audible feedback while using the device and is usually provided with at least one separate component. In the present embodiment of the invention, these functions of the device are performed without adding component parts. Preferably, the display element comprises an elastically deformable finger having a protrusion to engage with the clicker teeth. An additional clicker can be provided, which is active during dose setting.
    [0015] Preferably, the piston rod is a double threaded piston rod having a first external thread that fits with an internal thread of the housing and a second external thread that fits with an internal thread of the actuator, where the first and second threads can overlap each other at least partially. This allows to provide a mechanical advantage, that is, a transmission ratio (gear), in the device. Typically, the extent of selection of the button, that is, the distance by which the button rotates out of the housing during dose setting, will be greater than the distance by which the piston rod is displaced in relation to the cartridge holder and so to the cartridge. This allows dispensing exactly small amounts of a drug with maximum dispensing control by the user. The first and second outer threads may have a different pitch. However, it is preferable that the first and second outer threads have the same pitch, but are directed opposite.
    [0016] One of the external threads of the piston rod can be fitted with a corresponding internal thread of the housing, preferably an internal housing body. Thus, the piston rod rotates both during dose dispensing and during device reset, that is, when the piston rod is pushed (rotated) backwards.
    [0017] An additional reduction in the number of component parts can be achieved if the piston rod comprises a support fixed to the piston rod by means of at least one predefined break point. The support is axially restricted, but rotatable with respect to the piston rod after disengaging the support by destroying at least one predefined break point during or after assembly. Thus, only a single component has to be handled during assembly which in use fulfills the function of two separate components.
    [0018] According to a preferred embodiment, the actuator is a tubular element having a distal part that fits with a nut placed between the housing and the actuator, and a proximal part that at least partially surrounds a tubular part of the button. Preferably, one of the housing and the driver comprises at least one groove and the other of the housing and the driver comprises a threaded part with the nut placed between the housing and the driver, wherein the nut comprises at least one protuberance that it engages with at least one groove and a thread which engages with the threaded part, and in which the threaded part of the housing or the driver comprises an end of rotation stop. If the nut touches the end of rotation stop, further movement of the nut on the thread is prevented, thus preventing further rotation of the driver in relation to the housing that is required during dose setting. Thus, the nut can be used to limit the adjustable dose. This is, for example, required to prevent the establishment of a dose exceeding the amount of medication in the cartridge.
    [0019] Preferably, the housing comprises an outer body and an inner body with the cartridge holder being releasably coupled to the inner body. The inner body can be constrained rotationally and axially within the outer body in such a way that a cylindrical gap exists between the inner body and the outer body. Preferably, the inner body comprises an outer thread that engages with an inner thread of the display element and comprises at least one inner groove that engages with a protrusion of a clicker and / or a dose-limiting nut.
    [0020] In a standard mode, the internal body slots are axially aligned with the pen device. In an alternative embodiment, it is possible to reduce the dispensing force, increase the speed ratio and increase the thread pitch of the display element (that is, increase in the friction coefficient asymptote), by providing the internal body with at least one internal groove. which is twisted helically. In other words, the grooves are not aligned axially, which results in the actuator and button being displaced helically during dose dispensing. This may require adding an overcap to the button as an additional component preventing relative rotation with respect to a user's hand, typically the leg, during dose dispensing.
    [0021] If the actuator comprises a first component that fits into a threaded fitting with a nut and a second component, the first and second components can be operationally coupled together in a release mode. It is preferable that when a user establishes a dose by turning the knob, both the first component and the second component of the actuator rotate together. In addition, when a user resets the device, the first driver component is preferably decoupled from the second driver component and the first component is allowed to rotate with respect to the housing and with respect to the second component. The nut can be part of a dose limiter to prevent the establishment of a dose that exceeds the amount of liquid remaining in a drug delivery device cartridge. Thus, a simple and also reliable reset mechanism is provided by dividing the actuator into two components.
    [0022] The accuracy of a last-dose protection mechanism, that is, a dose limiter to prevent the establishment of a dose that exceeds the amount of liquid remaining in a drug delivery device cartridge, can be increased by the trigger being in threaded fitting with a nut, and the threaded fitting comprises a helical groove having a first step provided along a first part of the driver, a second step provided along a second part of the driver where the first step is smaller than the second step, and, optionally, a third step provided along a third part of the driver where the third step is less than the second step. Preferably, the second and third parts are located close to a rotational bathenterid, limiting further movement of the nut to prevent the establishment of a dose that exceeds the amount of liquid remaining in a drug delivery device cartridge. The pitch of the first part can be selected small to reduce the axial length of the device. The increased pitch of the second part results in a greater axial displacement of the nut in relation to the driver in such a way that the nut can pass through a relatively large and thus robust rotational stop.
    [0023] The drug delivery device may additionally comprise a clicker that produces a tactile and / or audible feedback during dose setting, that is, increasing or reducing the dose. This additional clicker may include a first toothed element rotatable with respect to the housing, a second toothed element rotated with respect to the actuator and a spring predisposing the first toothed element and the second toothed element for fitting.
    [0024] A transparent window can be provided in the accommodation to allow a user to see the numbers or the like on the display element indicating the established dose. Preferably, the housing comprises an inner body and an outer body with the window being attached to the housing by means of the first retaining device of the inner body and the second retaining device of the outer body.
    [0025] The basic function of the drug delivery device according to the present invention may include that a dose is selected by rotating a button component, which is helically displaced during dose setting. A dose can be delivered by pressing the same button component, which is now axially displaced during dispensing. Preferably, any dose size can be selected, in predefined increments, between zero and a maximum predefined dose, for example, 80 units. It is an additional advantage if the mechanism allows cancellation of a dose without medication being dispensed, for example, by rotating the button component in the opposite direction to that when selecting a dose.
    [0026] It is preferable that during dose setting the knob is rotated so that it drags the actuator and the display element in such a way that the button, the actuator and the display element are moved in a helical path with respect to the housing and the piston rod. Additionally, during dose dispensing the button is moved axially so that it drags the actuator and the display element in such a way that the button, the actuator and the display element are moved axially with respect to the housing and the piston rod, with the display element and the piston rod rotating with respect to the housing, the button and the actuator.
    [0027] To prevent malfunction or improper use of the device, the dose setting mechanism can be provided with stops preventing selection of a dose below zero unit or selection of a dose above a maximum dose. Preferably, rigid rotational stops are provided, for example, between the display element and the housing as a zero unit stop and / or as a maximum unit stop. If the housing comprises an inner body and an outer body, a first rotational stop can be provided between the inner body and the display element and a second rotational stop can be provided between the outer body and the display element to limit the rotational movement of the display element in relation to the housing. The minimum dose, usually zero units, can be defined by the first rotational stop and the maximum dose, for example, 60, 80 or 120 units, can be defined by the second rotational stop.
    [0028] The drug delivery device may comprise a cartridge containing a medicament. The term "medicine", as used herein, means a pharmaceutical formulation containing at least one pharmaceutically active compound,
    [0029] in which, in one embodiment, the pharmaceutically active compound has a molecular weight of up to 1,500 Da and / or is a peptide, a protein, a polysaccharide, a vaccine, a DNA, an RNA, an enzyme, an antibody or a fragment thereof, a hormone or an oligonucleotide, or a mixture of the pharmaceutically active compounds mentioned above,
    [0030] wherein in an additional embodiment the activopharmaceutical compound is useful for the treatment and / or prophylaxis of diabetes mellitus or complications associated with diabetes mellitus such as diabetic retinopathy, thromboembolism disorders such as deep vein or pulmonary thromboembolism, coronary syndrome acute (ACS), angina, myocardial infarction, cancer, macular degeneration, inflammation, hay fever, arteriosclerosis and / or rheumatoid arthritis,
    [0031] wherein in an additional embodiment the activopharmaceutical compound comprises at least one peptide for the treatment and / or prophylaxis of diabetes mellitus or complications associated with diabetes mellitus such as diabetic retinopathy,
    [0032] wherein in an additional embodiment the activopharmaceutical compound comprises at least one human insulin or a human insulin analog or derivative, a peptide such as glucagon (GLP-1) or an analog or derivative thereof, or exendin-3 or exendin -4 or an analogue or derivative of exendin-3 or exendin-4.
    [0033] Insulin analogues are, for example, human insulinGly (A21), Arg (B31), Arg (B32); human insulin Lys (B3), Glu (B29), Lys (B28), human insulin Pro (B29); human insulin Asp (B28); human insulin in which proline in position B28 is replaced by Asp, Lys, Leu, Val or Ala and in position B29 Lys can be replaced by Pro; human insulin Ala (B26); human insulin Des (B28-B30); human insulin Des (B27) and human insulin Des (B30).
    [0034] Insulin derivatives are, for example, human insulin B29-N-myristoyl-des (B30); human insulin B29-N-palmitoyl-des (B30); human insulin B29-N-myristoil; human B29-N-palmitoyl insulin; human insulin B28-N-myristoil-LysB28ProB29; human insulin B28-N-palmitoyl-LysB28ProB29; human insulin B30-N-myristoyl-ThrB29LysB30; human insulin B30-N-palmitoyl-ThrB29LysB30; human insulin B29-N- (N-palmitoyl-Y-glutamyl) -des (B30); human insulin B29-N- (N-litocholyl-Y-glutamyl) -des (B30); human insulin B29-N- (w-carboxyheptadecanoyl) -des (B30) and human insulin B29-N- (w-carboxyhepta-decanoyl).
    [0035] Exendin-4, for example, means Exendin-4 (1-39), an H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu- Ser-Lys-Gln sequence -Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu- Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro -Ber-NH2.
    [0036] Exendin-4 derivatives are, for example, selected from the following list of compounds:
    [0037] H- (Lys) 4-des Pro36, des Pro37 Exendin-4 (1-39) -NH2,
    [0038] H- (Lys) 5-des Pro36, des Pro37 Exendin-4 (1-39) -NH2,
    [0039] des Pro36 Exendina-4 (1-39),
    [0040] des Pro36 [Asp28] Exendina-4 (1-39),
    [0041] des Pro36 [IsoAsp28] Exendina-4 (1-39),
    [0042] des Pro36 [Met (O) 14, Asp28] Exendin-4 (1-39),
    [0043] des Pro36 [Met (O) 14, IsoAsp28] Exendin-4 (1-39),
    [0044] des Pro36 [Trp (O2) 25, Asp28] Exendina-4 (1-39),
    [0045] des Pro36 [Trp (O2) 25, IsoAsp28] Exendina-4 (1-39),
    [0046] des Pro36 [Met (O) 14 Trp (O2) 25, Asp28] Exendin-4 (1-39),
    [0047] des Pro36 [Met (O) 14 Trp (O2) 25, IsoAsp28] Exendin-4 (1-9); or
    [0048] des Pro36 [Asp28] Exendina-4 (1-39),
    [0049] des Pro36 [IsoAsp28] Exendina-4 (1-39),
    [0050] des Pro36 [Met (O) 14, Asp28] Exendin-4 (1-39),
    [0051] des Pro36 [Met (O) 14, IsoAsp28] Exendin-4 (1-39),
    [0052] des Pro36 [Trp (O2) 25, Asp28] Exendin-4 (1-39),
    [0053] des Pro36 [Trp (O2) 25, IsoAsp28] Exendina-4 (1-39),
    [0054] des Pro36 [Met (O) 14 Trp (O2) 25, Asp28] Exendin-4 (1-39),
    [0055] des Pro36 [Met (O) 14 Trp (O2) 25, IsoAsp28] Exendina-4 (1-39),
    [0056] wherein the -Lys6-NH2 group can be linked to the exendin-4-derived C-final;
    [0057] or an Exendin-4 derivative of the sequence
    [0058] des Pro36 Exendin-4 (1-39) -Lys6-NH2 (AVE0010),
    [0059] H- (Lys) 6-des Pro36 [Asp28] Exendin-4 (1-39) -Lys6-NH2,
    [0060] des Asp28 Pro36, Pro37, Pro38Exendin-4 (1-39) -NH2,
    [0061] H- (Lys) 6-des Pro36, Pro38 [Asp28] Exendin-4 (1-39) -NH2,
    [0062] H-Asn- (Glu) 5des Pro36, Pro37, Pro38 [Asp28] Exendin-4 (1-39) -NH2,
    [0063] des Pro36, Pro37, Pro38 [Asp28] Exendin-4 (1-39) - (Lys) 6-NH2,
    [0064] H- (Lys) 6-des Pro36, Pro37, Pro38 [Asp28] Exendin-4 (1-39) - (Lys) 6-NH2,
    [0065] H-Asn- (Glu) 5-des Pro36, Pro37, Pro38 [Asp28] Exendin-4 (1-39) - (Lys) 6-NH2, H- (Lys) 6-des Pro36 [Trp (O2 ) 25, Asp28] Exendin- 4 (1-39) -Lys6-NH2,
    [0066] H-des Asp28 Pro36, Pro37, Pro38 [Trp (O2) 25] Exendin-4 (1-39) -NH2,
    [0067] H- (Lys) 6-des Pro36, Pro37, Pro38 [Trp (O2) 25, Asp28] Exendin-4 (1-39) -NH2, H-Asn- (Glu) 5-des Pro36, Pro37, Pro38 [Trp (O2) 25, Asp28] Exendin-4 (1-39) -NH2, des Pro36, Pro37, Pro38 [Trp (O2) 25, Asp28] Exendin-4 (1-39) - (Lys) 6- NH2,
    [0068] H- (Lys) 6-des Pro36, Pro37, Pro38 [Trp (O2) 25, Asp28] Exendin-4 (1-39) - (Lys) 6-NH2, H-Asn- (Glu) 5- des Pro36, Pro37, Pro38 [Trp (O2) 25, Asp28] Exendin-4 (1-39) - (Lys) 6-NH2,
    [0069] H- (Lys) 6-des Pro36 [Met (O) 14, Asp28] Exendin-4 (1-39) -Lys6-NH2,
    [0070] des Met (O) 14 Asp28 Pro36, Pro37, Pro38 Exendin-4 (1-39) -NH2,
    [0071] H- (Lys) 6-desPro36, Pro37, Pro38 [Met (O) 14, Asp28] Exendin-4 (1-39) -NH2,
    [0072] H-Asn- (Glu) 5-des Pro36, Pro37, Pro38 [Met (O) 14, Asp28] Exendin-4 (1-39) -NH2, des Pro36, Pro37, Pro38 [Met (O) 14 , Asp28] Exendin-4 (1-39) - (Lys) 6-NH2,
    [0073] H- (Lys) 6-des Pro36, Pro37, Pro38 [Met (O) 14, Asp28] Exendin-4 (1-39) - (Lys) 6-NH2, H-Asn- (Glu) 5 des Pro36, Pro37, Pro38 [Met (O) 14, Asp28] Exendin-4 (1-39) - (Lys) 6-NH2,
    [0074] H-Lys6-des Pro36 [Met (O) 14, Trp (O2) 25, Asp28] Exendin-4 (1-39) -Lys6-NH2,
    [0075] H-des Asp28 Pro36, Pro37, Pro38 [Met (O) 14, Trp (O2) 25] Exendin-4 (1-39) -NH2, H- (Lys) 6-des Pro36, Pro37, Pro38 [ Met (O) 14, Asp28] Exendin-4 (1-39) -NH2,
    [0076] H-Asn- (Glu) 5-des Pro36, Pro37, Pro38 [Met (O) 14, Trp (O2) 25, Asp28] Exendin-4 (1-39) -NH2,
    [0077] des Pro36, Pro37, Pro38 [Met (O) 14, Trp (O2) 25, Asp28] Exendin-4 (1-39) - (Lys) 6-NH2, H- (Lys) 6-des Pro36, Pro37, Pro38 [Met (O) 14, Trp (O2) 25, Asp28] Exendin-4 (S1-39) - (Lys) 6-NH2,
    [0078] H-Asn- (Glu) 5-des Pro36, Pro37, Pro38 [Met (O) 14, Trp (O2) 25, Asp28] Exendin-4 (1-39) - (Lys) 6-NH2;
    [0079] or a pharmaceutically acceptable salt or solvate of any of the aforementioned Exendin-4 derivatives.
    [0080] Hormones are, for example, pituitary hormones or hypothalamic hormones or regulatory active peptides and their antagonists as listed in Rote Liste, ed. 2008, Chapter 50, such as Gonadotropin (Folitropin, Lutropin, Choriongonadotropin, Menotropin), Somatropin, Desmopressin, Terlipressin, Gonadoreelin, Triptorelin, Leuprorelin, Buserelin, Nafarelin, Goserelin.
    [0081] A polysaccharide is, for example, a glycosaminoglycan, a hyaluronic acid, a heparin, a low molecular weight heparin or an ultra low molecular weight heparin or a derivative thereof, or a sulfate, for example, a polysulfated form of polysaccharides mentioned above and / or a pharmaceutically acceptable salt thereof. An example of a pharmaceutically acceptable salt of a low molecular weight polysulfated heparin is enoxaparin sodium.
    [0082] Antibodies are globular plasma proteins (-150 kDa) that are also known as immunoglobulins that share a basic structure. Since they have sugar chains added to amino acid residues, they are glycoproteins. The basic functional unit of each antibody is an immunoglobulin (Ig) monomer (containing only one Ig unit); Secreted antibodies can also be dimeric with two Ig units such as IgA, tetramerics with four Ig units such as teleost fish IgM, or pentameric with five Ig units, such as mammalian IgM.
    [0083] The Ig monomer is a molecule modeled in "Y" that consists of four polypeptide chains; two identical heavy chains and two identical light chains connected by disulfide bonds between cysteine residues. Each heavy chain is about 440 amino acids long; each light chain is about 220 amino acids in length. Each of the heavy and light chains contains intrachain disulfide bonds that stabilize their folds. Each chain is made up of structural domains called Ig domains. These domains contain about 70-110 amino acids and are classified into different categories (for example, variable or V, and constant or C) according to their size and function. They have a characteristic immunoglobulin fold in which two β slides create an interspersed "" shape, held together by interactions between conserved cysteines and other charged amino acids.
    [0084] There are five types of mammalian Ig heavy chain denoted by α, δ, ε, Y and μ. The type of heavy chain present defines the antibody isotype; these chains are found in IgA, IgD, IgE, IgG and IgM antibodies, respectively.
    [0085] Different heavy chains differ in size and composition; α and y contain approximately 450 amino acids and δ approximately 500 amino acids, while μ and ε have approximately 550 amino acids. Each heavy chain has two regions, the constant region (CH) and the variable region (VH). In one species, the constant region is essentially identical in all antibodies of the same isotype, but differs in antibodies of different isotypes. The heavy chains y, α and δ have a constant region made up of three tandem Ig domains, and a hinge region for added flexibility; the heavy chains μ and ε have a constant region made up of four immunoglobulin domains. The variable region of the heavy chain differs in antibodies produced by different B cells, but it is the same for all antibodies produced by a single B cell or B cell clone. The variable region of each heavy chain is approximately 110 amino acids in length and is composed of a single Ig domain.
    [0086] In mammals, there are two types of imu-noglobulin light chains denoted by À and K. A light chain has two successive domains: a constant domain (CL) and a variable domain (VL). The approximate length of a light chain is 211 to 217 amino acids. Each antibody contains two light chains that are always identical; only one type of light chain, K or À, is present by antibody in mammals.
    [0087] Although the general structure of all antibodies is very similar, the exclusive property of a given antibody is determined by means of the variable regions (V), as detailed above. More specifically, variable bonds, three in each light chain (VL) and three in the heavy chain (VH), are responsible for binding to the antigen, that is, its antigen specificity. These ties are referred to as the Complementarity Determination Regions (CDRs). Because CDRs from both the VH and VL domains contribute to the antigen binding site, it is the combination of the heavy and light chains, and not one or the other alone, that determines the specificity of the final antigen.
    An "antibody fragment" contains at least one antigen binding fragment as defined above, and exhibits essentially the same function and specificity as the complete antibody from which the fragment is derived. Limited proteolytic digestion with papain divides the Ig prototype into three fragments. Two identical amino terminal fragments, each containing a total L chain and about half an H chain, are the antigen-binding (Fab) fragments. The third fragment, similar in size, but containing the carboxyl terminal half of both heavy chains with their inter-chain disulfide bond, is the crystallizable fragment (Fc). Fc contains carbohydrates, complement binding and FcR binding sites. Limited pepsin digestion produces a single F (ab ') 2 fragment containing both the Fab parts and the hinge region, including the H-H interchain disulfide bond. F (ab ') 2 is divalent for antigen binding. The disulfide bond of F (ab ') 2 can be split in order to obtain Fab'. In addition, the variable regions of the heavy and light chains can be fused together to form a single variable chain fragment (scFv).
    [0089] Pharmaceutically acceptable salts are, for example, acid addition salts and basic salts. Acid addition salts are, for example, the HCl or HBr salts. Basic salts are, for example, salts having a cation selected from alkali or alkali, for example, Na +, or K +, or Ca2 +, or an N + (R1) (R2) (R3) (R4) ammonium ion, where R1 to R4 independently of one another means: hydrogen, an optionally substituted C1-C6 alkyl group, an optionally substituted C2-C6 alkenyl group, an optionally substituted C6-C10 aryl group, or an optionally substituted C6-C10 heteroaryl group. Additional examples of pharmaceutically acceptable salts are described in "Remington's Pharmaceutical Sciences" 17. ed. Alfonso R. Gennaro (Ed.), Mark Publishing Company, Easton, Pa., USA, 1985 and in the Encyclopedia of Pharmaceutical Technology.
    [0090] Pharmaceutically acceptable solvates are, for example, hydrates.
    [0091] An exemplary non-limiting embodiment of the invention will now be described with reference to the accompanying drawings, in which:
    [0092] Figure 1 shows a drug delivery device with a cap attached in accordance with the present invention;
    [0093] Figure 2 shows the drug delivery device of figure 1 with the cap removed and a dose of 79 units selected;
    [0094] Figure 3 shows in an exploded view the components of the drug delivery device of figure 1;
    [0095] Figure 4 shows the external body of the drug delivery device of figure 1;
    [0096] Figure 5a shows the internal body of the drug delivery device of figure 1;
    [0097] Figure 5b shows a detail of the internal body of figure 5a;
    [0098] Figure 6 shows the cartridge holder of the drug delivery device of figure 1;
    [0099] Figure 7a shows a first component of display element of the drug delivery device of figure 1;
    [00100] Figure 7b shows a detail of the first display element of figure 7a;
    [00101] Figure 8 shows a second component of display element of the drug delivery device of figure 1;
    [00102] Figure 9 shows a first driver component of the drug delivery device of Figure 1;
    [00103] Figure 10 shows a second driver component of the drug delivery device of figure 1;
    [00104] Figure 11 shows a third driver component of the drug delivery device of figure 1;
    [00105] Figure 12 shows the last dose nut of the drug delivery device of figure 1;
    [00106] Figure 13 shows a coupling component of the drug delivery device of figure 1;
    [00107] Figure 14 shows a first clicker component of the drug delivery device of Figure 1;
    [00108] Figure 15 shows a second clicker component of the drug delivery device of Figure 1;
    [00109] Figure 16 shows the button of the drug delivery device of figure 1;
    [00110] Figure 17 shows a cut-away view of the proximal part of the drug delivery device of figure 1 in a position of zero unit with the button released;
    [00111] Figure 18 shows a cut-away view of the proximal part of the drug delivery device of figure 1 in a position with some units selected; and
    [00112] Figure 19 shows a cropped view of the proximal part of the drug delivery device of figure 1 in a position of zero unit with the button pressed.
    [00113] Figures 1 and 2 show a drug delivery device 1 in the form of an injection pen. The device has a distal end (lower end in figure 1) and a proximal end (upper end in figure 1). The component parts of the drug delivery device 1 are shown in figure 3 in more detail. The drug delivery device 1 comprises an outer housing part 10, an inner body 20, a piston rod 30, a driver 40, a nut 50, a display element 60, a button 70, a cartridge holder 80 for receive a cartridge 81, a coupling 90, a clicker 100, a spring 110, a cap 120 and a window insert 130. A needle arrangement (not shown) comprising a needle hub and a needle cover can be provided as a component additional, which can be exchanged as explained above. The piston rod 30 comprises a support 31. The driver comprises a distal driver part 41, a proximal driver part 42 and a coupler 43. The display element 60 comprises a numbering sleeve 61 and a selection sleeve 62. The The clicker comprises a distal clicker part 101, a proximal clicker part 102 and a spring 103.
    [00114] The outer housing part 10, which is shown in figure 4, is a generally tubular element having a distal part 11 for securing the inner body 20 and a proximal part, which is provided with a rigid stop rotational 12 on its internal surface (not shown) which contacts wedding faces of the display element 60 when the maximum units stop (in this example 80U) is engaged. The end face also serves as the dose dispensing stop end for button 70, and the hole in the end face centers display element 60 during both selection and dispensing. An opening 13 is provided to receive the window insert 130. The outer body 10 provides the user with a surface to grasp and react against during dispensing.
    [00115] The internal body 20 is a generally tubular element having regions of different diameters. As can be seen in figures 17 to 19, the inner body 20 is received inside the outer body 10 and permanently fixed there to prevent any relative movement of the inner body 20 with respect to the outer body 10. The inner body has the functions to accommodate the drive mechanism inside it, guide the clickers and the last dose nut 50 via internal grooves, to provide an internal thread through which the piston rod 30 (lead screw) is driven, to support and guide the sleeve number 61 and selection sleeve 62 in an external thread form, for securing the cartridge holder 80 and for securing the outer body 10 and the window insert 130.
    [00116] The outermost diameter of the inner body 20 also forms part of the visual design and remains visible when the cap 120 is attached to the cartridge holder 80 as a ring separating the cap 120 from the outer body 10. This visible ring also has depressions that line up with the cap fitting features on cartridge holder 80 to indicate that the cartridge holder is seated correctly.
    [00117] An external thread 21 is provided on the external surface of the internal body 20. Additionally, the grooves 22 (figure 5b) are provided on the internal surface of the internal body 20. These internal grooves 22 guide the proximal part of the clicker 102 axially during both selection and dispensing and also prevent the last dose 50 nut from turning. Some of the grooves can be wider to ensure correct rotational assembly of the internal components, and these wider grooves can have a stepped entry to stimulate the last dose nut 50 which has beveled outer wedding ribs to rotate against the stop face on the sleeve. distal drive 41 during assembly. At the open end shown in figure 5b there are additional short grooves which together with the alternating long grooves 22 are used to rotate the button 70 (dose selector handle) rotatively at the end of the dispensing and serve to increase the resistance of the dial stop. 0U when button 70 is pressed. This is achieved by fitting with male key features 94 in the coupling component 90.
    [00118] Bayonet features 23 guide cartridge holder 80 into the mechanism during cartridge replacement, compressing cartridge predisposition spring 110, and then retract cartridge holder 80 a short distance to reduce axial clearance in the mechanism. Docking features within the inner body 20 lock the cartridge holder 80 pivotally when it has been properly seated. The profile of these pressure fittings is intended to prevent the user from partially engaging the cartridge holder 80, the cartridge predisposition spring 110 to eject the cartridge holder 80 if the pressure fittings have not at least initiated the fitting. A window retaining tip 24 retains the window insert 130 when the outer body assembly 10 and the window insert 130 are axially inserted into the inner body 20. Two diametrically opposed stop faces 25 define the final rotational position for the numbers 61. This end position is the end of the dose holder position for the minimum dose (0U).
    [00119] The piston rod 30 is an elongated element having the two external threads 32, 33 with opposite hand that overlap each other. One of these threads 32 fits with the internal thread of the inner body 20. A support such as disc 31 is provided at the distal end of the piston rod 30. The support 31 can be a separate component as shown in figure 3 or can be attached to the piston rod 30 as a one-piece component by means of a predetermined breaking point.
    [00120] The piston rod 30 transfers the dispensing load from the driver 40 to the support 31, creating a mechanical advantage greater than 1: 1 by converting the torque generated in the piston rod 30 through the thread interface of the driver 40 for axial load additional as the piston rod passes through the thread on the inner body 20. The piston rod 30 is reset by pressing on the bracket 31 and this in turn rotates the piston rod back to the inner body 20. This disengages and then rotates the distal drive sleeve 41, resetting the last dose nut 50 back to its starting position on the distal drive sleeve 41.
    [00121] The actuator 40 is an element in a general tubular manner having in the modality shown in the figures three components which are represented in figures 9 to 11 in more detail.
    [00122] The distal drive sleeve 41 fits with the piston rod thread 33 to drive the piston rod 30 through the internal body 20 during dose delivery. The distal drive sleeve 41 is also permanently connected to the coupler 43 which in turn is releasably attached via reset coupling features to the proximal drive sleeve 42. The two halves of the drive sleeve are connected rotationally and axially during selection and dispensing, but are rotationally uncoupled during device restoration in such a way that they can rotate relative to each other.
    [00123] The external thread 44 fits with the last dose nut 50. The thread form has three stages, a first shallow stage (left side in figure 9) over which the nut 50 is moved to count most of the units selected, a rapid stage on which the last dose nut is moved rapidly axially before engaging with the stop faces, and a final shallow section that ensures that, when the stop faces are engaged, the axial restraint on the nut 50 extends over a reasonable length of the thread form. Four equidistant stop faces 45 mate with the wedding stop faces 51 on the last dose nut 50 to limit the number of units that can be selected. The keys 46 are provided at the proximal end of the distal drive sleeve 41 to transfer torque from the coupler 43 or to it, which can be snapped into the distal drive sleeve 41.
    [00124] The proximal drive sleeve 42 shown in figure 10 supports the components of the clicker 100 and the coupling 90 and transfers rotational movement from the dose knob 90 to the coupler 42 and to the distal drive sleeve 41.
    [00125] The tooth features 47 located at the distal end of the proximal drive sleeve 42 fit with the reset coupling features on coupler 43 to connect both drive sleeve halves during selection and dispensing. During restoration these teeth 47 disengage.
    [00126] Several grooves are provided on the external surface of the proximal drive sleeve 42 that fit with the distal part of clicker 101, preventing relative rotation during selection and dispensing. Additional grooves, which are located in the central region of the proximal drive sleeve 42, fit with the coupling component 90. They can be arranged so as not to be rotationally symmetrical in such a way that the various clicker components cannot be accidentally mounted upside down.
    [00127] The proximal part of the proximal drive sleeve 42 has four arms or fingers 48. A support surface such as hook 49 exists at the bottom (as seen in figure 10) of flange segments at the end of the flexible fingers 48 The flexible fingers 48 are separated with clearances or slots that create space for the button 70 to fit with the coupling 90 and which also enable these fingers to flex inwards during the assembly of the proximal drive sleeve 42 in the selection sleeve 62. After assembly the hooks 49 retain the proximal drive sleeve 42 in relation to the selection sleeve 62 under the reaction force of the spring 103. During dispensing the button 70 presses the spring 103 via coupling 90 and the clicker components and this spring force 103 is transferred via coupler 43 for the proximal drive sleeve 42 which then through these support surfaces applies axial load to the selection sleeve 62. This axial load drives the selection sleeve 62 and consequently and the number sleeve 61 along the helical thread of the inner body 20, back to the body of the device, until the 0U stop faces in the number sleeve 61 contact the inner body 20.
    [00128] Coupler 43 shown in figure 11 rotatably couples the two halves of the drive sleeve together during selection and dispensing, while allowing them to be detached during restoration. Coupler 43 also has to transfer the last dose protective stop load from the proximal drive sleeve 42 to the distal drive sleeve 41. Two sets of teeth are provided on the coupler 43 to fit with teeth 46 and teeth 47, respectively. Coupler 43 is fitted to the distal drive sleeve 41 allowing limited relative axial movement with respect to the proximal drive sleeve 42.
    [00129] Nut 50 is provided between the inner body 20 and the distal drive sleeve 41 of the driver 40. The stop faces 51 are located on the proximal face of the last dose nut 50 to limit the number of units that can be selected if the stop faces 51 contact the stops 45 of the distal drive sleeve 41. The function of the last dose nut 50 is to prevent the user from selecting beyond a finite amount. This limit is based on the disposable volume of cartridge 81 and when reached the user must replace cartridge 81 and reset the device.
    [00130] The outer ribs 52 of the nut 50 fit with the grooves 22 of the inner body 20. An inner thread 53 of the nut fits with the outer thread 44 of the distal drive sleeve 41. As an alternative, grooves and ribs can be provided in the interface between nut 50 and driver 40 and threads can be provided at the interface between nut 50 and inner body 20. As an additional alternative, nut 50 can be designed, for example, as a half nut.
    [00131] The display element 60 is a generally tubular element that is composed of the numbering sleeve 61 and the selection sleeve 62 which are joined together during assembly to axially and rotatively restrict these two components, which act as well as a single part.
    [00132] The main functions of the number 61 sleeve shown in figure 8 are to provide a surface, on which numbers of doses can be printed to display the selected dose, to guide the helical path of the internal mechanism during selection to follow the thread shape helical on the piston rod 30 when inserted into the internal body 20 and for attachment to the selection sleeve 62. The numbering sleeve 61 is designed to be entirely enclosed in the external body 10 during selection and dispensing and for this reason only the selected dose is visible to the user by opening a window. The numbering sleeve has a 0U (minimum dose) stop face 63 to limit its travel when selected, but the 80U (maximum dose) stop faces that limit the selected condition are located on selection sleeve 62. At the end of each dispensing stroke this stop face 63 engages with the matching surface 25 on the inner body 20 to limit the rotational position of the number sleeve 61.
    [00133] A helical drive face 64 forms a thread that guides the number 61 sleeve during selection and dispensing to follow the helical path 21 in the inner body.
    [00134] The selection glove 62 is mounted on the number glove 61 in such a way that, once assembled, no relative movement is allowed. The parts are made as separate components to enable both molding and assembly. Also, while the number glove 61 is preferably white to provide contrast, for example, for black dose numbers, the color of the selection glove 62 can be chosen to satisfy aesthetics or possibly to distinguish the type of drug.
    [00135] At the proximal end, the selection sleeve 62 has the internal coupling features 65 that fit with the coupling component 90 during selection and disengage from the coupling during dispensing. These coupling features 65 rotationally lock the selection sleeve 62 to the coupling 90 during selection and when the 0U and 80U stops are engaged. When button 70 is pressed these coupling features disengage to allow coupling 90 and drive mechanism to be displaced axially while selection sleeve 62 and number sleeve 61 rotate back to the 0U start position.
    [00136] The selection sleeve 62 rotates out during selection by fitting it with the coupling 90 and the numbering sleeve 61, and rotates backwards during dispensing under the axial force applied by the proximal drive sleeve 42 to a face of support such as flange 66 at the end of the selection sleeve. This support face 66 fits with the flexible arms 48 of the proximal drive sleeve 42 during dispensing. Two diametrically opposed faces 67 fit with the outer body 10 when the maximum dose (for example, 80U) has been selected, forming the maximum dose stop faces.
    [00137] A ratchet arm 68 fits with ratchet features to button 70 (dose selector handle) to provide audible feedback during dispensing, giving a click per unit delivered. In addition, this prevents the user from grasping and rotating the number sleeve 61 out of a partially selected position while holding the button 70 down. This would rewind piston rod 30 which would result in a lower dose than the subsequent selected dose. This can additionally reinforce the 0U stop.
    [00138] The button 70 shown in figure 16 serves as a dose selector handle and is retained by the coupling 90 to transfer the user's actions to the coupling. It also carries the ratchet teeth 71 that fit with the ratchet arm 68 into the selection sleeve 62, which serves as the dispensing clicker giving audible feedback (ratchet clicks), and an end face 72 that serves as the face dose termination stop with outer body 10. This end face 72 thus serves to define the final position during dispensing when it contacts outer body 10 to provide a very positive stop improving dose accuracy.
    [00139] A central part such as sleeve of button 70 is provided with four arms 73 having fitting features such as hooks 74 at their respective distal ends. The arms 73 form grooved surfaces that fit with the coupling 90 to transfer torque from the button 70 through the coupling to the selection sleeve 62 and to the proximal drive sleeve 42. The fitting features 74 fit holes in the coupling 90 and are designed with angled recessed faces to hold snaps when an axial load is applied to pull the button 70 out of the pen body 10. The space between the arms 73 defines areas giving clearance to the flexible arms 48 of the proximal drive sleeve 42 to slide freely in relation to button 70 and coupling 90 when button 70 is pressed and released during dose dispensing.
    [00140] The cartridge holder 80 is fixed to the internal body 20 with a bayonet connection 82 and houses the glass ampoule or cartridge 81 containing the medication to be dispensed. The cartridge holder 80 includes an opening 83 on the rear face (as seen in figure 6) which, if gripped by the user, prevents the ampoule from falling out when the cartridge holder is removed from the inner body 20. The front face is printed with a scale of number of doses. The threaded distal end 84 is used to attach disposable pen needles.
    [00141] A tubular coupling 90 is provided between the display element 60 and the button 70. The coupling is fixed in relation to the button 70, and retains the same, and together they move axially in relation to the proximal drive sleeve 42 when the button 70 is pressed during dispensing, disengaging the coupling teeth from the selection sleeve 62. It also transfers torque from the button to the proximal drive sleeve 42, and the selection stop and 0U / 80U loads from the button via coupling for selection glove and number glove.
    [00142] The keys of the drive sleeve 91 provided on an internal surface of the coupling fit with the proximal drive sleeve 42. On the distal end face, the coupling pre-arrangement teeth 92 are provided that match the similar teeth 109 in the proximal part of clicker 102 to ensure that in the button out of position (selected dose) the coupling is locked in rotation to the proximal part of clicker 102 under the action of predisposition of the coupling spring 103. Teeth 92 are shallow in height to prevent that the proximal part of clicker 102 fits with grooves in the proximal drive sleeve 42 during selection. Four slot holes 93 serve to retain the slot 74 features of button 70. Near its proximal end, the coupling has keys 94 that at the end of dispensing with button 70 pressed lock the inner body 20 to prevent the user from turning button 70 stops below the 0U position.
    [00143] Coupling teeth 95 engage with coupling teeth 65 of the selection sleeve to rotate the button 70 via coupling to the number 61 sleeve. During dispensing the coupling is displaced axially in order to disengage these coupling teeth 95 to release the selection sleeve 62 to rotate back to the device while the coupling 90 and consequently the driver 40 are displaced axially to dispense the dose.
    [00144] The clicker 100 comprises a distal clicker part 101, a proximal clicker part 102 and a spring 103. The coupling spring 103 serves to predispose the button 70 outward in such a way that at the end of a dose the button 70 it moves quickly outwards, refitting the coupling 90 with the selection sleeve 62 ready for selection. In addition, it provides the spring force for the clicker components to act as clickers and also as holding positions for the number 61 sleeve. In addition, it retains the two drive sleeve halves 41, 42 in rotating engagement during selection and dispensing, allowing them to be detached during device reset.
    [00145] The distal part of clicker 101 is permanently joined by means of a key to the proximal drive sleeve 42 and fits with the proximal part of clicker 102 which in turn is joined by means of a keyway to the internal body 20. During selection when drive sleeve is rotated relative to the inner body, the two clickers 101, 102 rotate relative to each other under the compression force of the coupling spring 103. This force combined with the clicker teeth formed on the end face of each clicker provides the clicks as well as the holder selection positions.
    [00146] During dispensing the two clickers 101, 102 are pressed together under the dispensing load and for this reason prevent relative rotation between the proximal drive sleeve 42 and the inner body 20, driving the piston rod forward to deliver the dose . The grooves 104 in the inner hole rotatively connect the distal part of clicker 101 to the proximal drive sleeve 42 at all times, but allow free axial movement when the button 70 is pressed during dispensing and when the two clickers are superimposed on each other during selection . The profiles of clicker teeth 105, 106 in both the distal part of clicker 101 and the proximal part of clicker 102 are identical and overlap each other under the compressive load of spring 103 during selection.
    [00147] The proximal part of clicker 102 is permanently joined by means of a key to the internal body 20 by the external keys 107 which prevent relative rotation with the internal body during both selection and dispensing, providing clicks during selection and locking the proximal actuation sleeve 42 in rotation during dispensing. The additional cylindrically shaped keys 108 also couple the clicker proximal part 102 rotatively to the proximal triggering sleeve 42 when the button 70 is pressed, thus preventing the user from selecting more than 80 units with the button pressed. The proximal clicker portion 102, in addition to the primary clicker teeth 106, has the coupling predisposing teeth 109 on the opposite end face. These teeth match the similar teeth 92 on the coupling to ensure that with the button out of position (selected dose) the coupling is locked in rotation with respect to the proximal part of clicker 102 under the action of predisposition of the coupling spring 103.
    [00148] The cartridge predisposition spring 110 is mounted as two components one after the other, the first lower and the second upper. The spring combination serves to apply a final charge to cartridge 81 at tolerance ends in order to predispose it forward to the end face of the ferrule in cartridge holder 80. This ensures that when the user removes and attaches a needle , the friction between the needle cannula and the cartridge septum does not move the cartridge 81 axially with respect to the cartridge holder 80. The pre-disposition spring 110 also acts to provide a force against which the user has to connect the cartridge holder. cartridge 80 and this can be added to the tactile feedback of this bayonet connection. The spring 100 also serves to eject the cartridge holder 80 if the cartridge holder is not rotated to a safe position, highlighting this error for the user.
    [00149] The cap 120 serves to protect the cartridge holder 80 from damage and the cartridge 81 itself against dust entering the area around the septum. The cap is designed to accommodate a standard pen injector needle.
    [00150] The window insert 130 may include a lens to enlarge the number of doses, for example, by approximately 25% from its printed size. The window insert 130 can be printed on the back to protect the printed surface against abrasion and also to maximize the light entry through the window opening, giving uniform illumination of the number of doses and white area around these numbers. Arrows can be printed adjacent to the window opening that indicate the selected dose.
    [00151] In the following, the function of the drug delivery device and its components will be explained in more detail with reference to figures 17 to 19.
    [00152] To use the device, a user has to select a dose. In the initial condition (at rest) as shown in figure 17 the display element 60 indicates the number of doses selected by the user. The number of selected units can be seen through the dose window 130 on the outer body 10. Because of the threaded fit between the display element 60 and the inner body 20, the knob 70 rotates clockwise causing the display element 60 to rotate out of the device and incrementally count the number of units to be delivered. Figure 18 shows an intermediate selection stage (for example, 7 out of 80 units).
    [00153] During dose setting the button 70, the actuator 40 and the display element 60 are rotated jointly together via coupling 90. Additionally, the button 70, the actuator 40 and the display element 60 are axially coupled. Thus, these three components rotate out of the outer housing 10 during dose setting. Clockwise rotation of knob 70 causes the actuator 40 to rotate and as a result it advances along the piston rod 30 which remains fixed throughout the selection. The clicker arrangement 100 provides tactile and audible feedback to the user when selecting doses. At the maximum selectable dosage of 80 units, stop features 12 and 67 snap together to prevent further selection.
    [00154] The last dose nut 50 provides the function of counting the number of units dispensed. Nut 50 locks the device at the end of the cartridge life and as such no drug can be selected by the user anymore. The last dose nut 50 and the driver 40 are connected by means of a threaded interface as explained above. In addition, the last dose nut 50 is mounted in the grooves 22 in such a way that the nut 50 and the inner body 20 are rotated together (at all times). Rotation of the driver 40 during selection causes the nut 50 to advance along the thread 44. The nut 50 is free to slide axially within the inner body 20 at all times that allow the nut to advance. The change in pitch of the thread 44 shown in figure 9 in the direction of the final doses axially accelerates the advance of the nut 50 to the end of the cartridge life blocking condition. At the end of the life condition, the stop resources 51 of the last dose nut 50 contact the corresponding resources 45 in the driver 40. The contact by means of the key with the inner body 20 reacts to any torque transmitted by these stop resources 45.
    [00155] With the desired dose selected, device 1 is ready for dose dispensing. This basically requires pushing the button 70 which will result in a disengagement of the coupling 90 from the selection sleeve 62 thus allowing relative rotation between the display element 60 and the button 70. In all conditions the actuator 40 and the button 70 are rotated joined together by the attachment of the arms 73 and the fingers 48 and the keys 91, fitting with corresponding grooves in the proximal drive sleeve 42. Thus, with the coupling 90 disengaged (button 70 pushed inwards), the button 70 and the driver 40 are rotated together with the button 70, the driver 40 and the display element 60 still being axially coupled.
    [00156] When dispensing a dose, the dose button 70 and the coupling 90 are moved axially in relation to the mechanism by compressing the coupling spring 103. Because the proximal part of clicker 102 is joined by means of a key to the body internal 20 and the axial load passing through clicker teeth 105, 106 lock the distal part of clicker 101 in rotation in relation to the proximal part of clicker 102, the mechanism is forced to move axially while the selection glove 62 and the numbering sleeve 61 is free to rotate back into the outer housing 10. The interplay of matching threads between the piston rod 30, the driver 40 and the inner body 20 provides a mechanical advantage of 2: 1. In other words, advancing the actuator 40 axially causes the piston rod 30 to rotate, which because of the threaded fit of the piston rod 30 with the inner body 20 advances the piston rod. During dispensing the dose dispensing clicker 68, 71 is active which involves the button 70 and the display element 60. The dispensing clicker primarily provides audible feedback to the user that the drug is being dispensed.
    [00157] The end of this step is shown in figure 19. At this point the dose is complete and, when the user removes the force from the end of the dose button 70, the coupling spring 103 pushes this dose button 70 back, engaging teeth 65 and 95 again between the coupling and the selection sleeve.
    [00158] Restoring the device begins with removing the cartridge holder 80 and replacing an empty cartridge with a full cartridge 81. As the cartridge holder is refitted, the stopper of the new cartridge contacts the holder 31, thus pushing the piston rod 30 back into the housing. Initially, the piston rod 30 is screwed into the internal body 20, thereby axially disengaging the coupler 43 from the proximal drive sleeve 42 against the predisposing force of the spring 103. Once the coupler 43 is disengaged, it is free to start rotate together with the distal drive sleeve 41 and continues to do so as the cartridge holder 80 is axially displaced to fit with the inner body 20. Thus, the distal drive sleeve 41 rotates with respect to the proximal drive sleeve 42 which is still rotationally constrained in the inner body 20 as the clicker parts 101 and 102 are pressed together by the spring-loaded spring 103. As the distal drive sleeve 41 rotates, the last dose nut 50 is reset to its start position (distal). Coupling the cartridge holder 80 to the inner body 20, the mechanism recedes because of the bayonet structure 23 allowing the proximal drive sleeve 42 to be re-fitted with the coupler 43 and thus the distal drive sleeve 41.
    权利要求:
    Claims (15)
    [0001]
    1. Reusable drug delivery device for selecting and dispensing a number of variable doses of a drug user, comprising a housing (10, 20), a cartridge holder (80) for retaining a cartridge (81) containing the medicine, a piston rod (30) movable in relation to the cartridge holder (80), a driver (40) coupled to the piston rod (30), a display element (60) to indicate an established dose and being coupled to the housing (10, 20) and the driver (40), a coupling (90) for rotatingly coupling the driver (40) to the housing (10, 20) or display element (60) and a button (70) rotatingly coupled to the coupling (90) and the actuator (40), characterized by the fact that the drug delivery device comprises at least two of the following features: - the actuator (40) is in threaded fit with the piston rod (30) , permanently rotated to the button (70), which can be axially displaced in relation to the bo so (70) and comprises at least two separate components (41, 42) which are rotatably coupled during dose setting and during dose dispensing and which are rotatably uncoupled during reset of the device, - the display element (60) has an end distal provided with an internally extending thread (64) and a proximal end provided with an internally extending flange (66), wherein the display element (60) comprises two separate components (61, 62) with a first component (61 ) comprising the thread (64) and the other component (62) comprising the flange (66), - the button (70) comprises fingers (73) which engage with corresponding slots of the actuator (40) for rotatingly coupling the button (70) to the driver (40) and which comprise fitting features (74) which fit with corresponding fitting features (93) of the coupling (90) to axially couple the button (70) to the coupling (90), - the driver (40) comprises fingers (4 8) which fit with corresponding slots of the button (70) to rotatively couple the button (70) to the actuator (40) and which comprise features of hooks (49) which fit with corresponding contact features (66) of the display element (60 ) to axially couple the actuator (40) to the display element (60), - the button (70) comprises a ring of clicker teeth (71) which fits with a corresponding clicker feature (68) of the display element (60 ) at least during dose dispensing.
    [0002]
    2. Drug delivery device according to claim 1, characterized in that the piston rod (30) is threaded with the housing (10, 20) in such a way that the piston rod (30) is rotated during dose dispensing and device reset.
    [0003]
    Drug delivery device according to claim 1 or 2, characterized in that the piston rod (30) is a double threaded piston rod having a first external thread (32) that fits with an internal thread of the housing (20) and a second external thread (33) which engages with an internal thread of the driver (40), in which the first and second external threads (32, 33) overlap at least partially.
    [0004]
    Drug delivery device according to claim 3, characterized in that the first and second external threads (32, 33) have the same pitch.
    [0005]
    Drug delivery device according to any one of the preceding claims, characterized in that the piston rod (30) comprises a support (31) fixed to the piston rod (30) by means of at least one point predefined break, in which the support is axially restricted, but rotatable with respect to the piston rod (30) after disengaging the support (31) by destroying at least one predefined break point.
    [0006]
    6. Drug delivery device according to any one of the preceding claims, characterized in that the actuator (40) is a tubular element having a distal part (41) that fits with a nut (50) placed between the housing ( 10, 20) and the driver (40), and a proximal part (42) that at least partially surrounds a tubular part of the button (70).
    [0007]
    Drug delivery device according to any one of the preceding claims, characterized in that the actuator (40) comprises a first component (41) that is threaded in place with a nut (50) and a second component (42 ), the first and second components being operationally coupled together in such a way that when a user establishes a dose by turning the knob (70), both the first component (41) and the second component (42) of the actuator rotate together, and in such a way that when a user restores the device the first component (41) of the driver (40) is detached from the second component (42) of the driver (40) and the first component (41) is allowed to rotate with the housing (10, 20) and the second component (42).
    [0008]
    Drug delivery device according to any one of the preceding claims, characterized in that the actuator (40) is in a threaded socket with a nut (50), and in which the threaded socket comprises a helical groove (44) having a first step provided along a first part of the driver (40), a second step provided along a second part of the driver (40) in which the first step is less than the second step, and optionally a third step provided along a third part of the driver (40) in which the third step is less than the second step.
    [0009]
    Drug delivery device according to claim 7 or 8, characterized in that the nut (50) is part of a dose limiter to prevent the establishment of a dose that exceeds the amount of liquid remaining in a cartridge (81) of the drug delivery device.
    [0010]
    Drug delivery device according to any one of the preceding claims, characterized in that it additionally comprises a clicker (100) having a first toothed element (102) rotationally restricted in relation to the housing (10, 20), a second toothed element (101) rotationally restricted in relation to the actuator (40) and a spring (103) predisposing the first toothed element (102) and the second toothed element (101) for fitting.
    [0011]
    Drug delivery device according to any one of the preceding claims, characterized in that the housing (10, 20) comprises an inner body (20) and an outer body (10) and a window (130) attached to the housing (10, 20) by means of the first retaining device (24) of the inner body (20) and the second retaining device of the outer body (10).
    [0012]
    Drug delivery device according to any one of the preceding claims, characterized in that the housing (10, 20) comprises an inner body (20) and an outer body (10) and in which the inner body (20 ) comprises at least one internal groove which is twisted helically.
    [0013]
    13. Drug delivery device according to any one of the preceding claims, characterized in that the housing (10, 20) comprises an inner body (20) and an outer body (10) with a first rotational stop (25) provided between the inner body (20) and the display element (60) and a second rotational stop (12) provided between the outer body (10) and the display element (60) limiting the rotational movement of the display element (60 ) in relation to the housing (10, 20) between a minimum dose defined by the first rotational stop (25) and a maximum dose defined by the second rotational stop (12).
    [0014]
    14. Drug delivery device according to any one of the preceding claims, characterized by the fact that during dose setting the button (70) is rotated in such a way that it drags the actuator (40) and the display element (60) from such that the button (70), the actuator (40) and the display element (60) are moved in a helical path with respect to the housing (10, 20) and the piston rod (30), and during dose dispensing the button (70) is moved axially so that it drags the actuator (40) and the display element (60) in such a way that the button (70), the actuator (40) and the display element (60 ) are displaced axially with respect to the housing (10, 20) and the piston rod (30), with the display element (60) and the piston rod (30) rotating with respect to the housing (10, 20), when button (70) and the trigger (40).
    [0015]
    Drug delivery device according to any one of the preceding claims, characterized in that it additionally comprises a cartridge (81) containing a medicament.
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    公开号 | 公开日
    JP2015526217A|2015-09-10|
    PL2890435T3|2020-09-07|
    IL236746A|2020-02-27|
    MX2015002634A|2015-06-24|
    EP2890435B1|2020-03-04|
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    US20160235923A1|2016-08-18|
    KR20150052061A|2015-05-13|
    IL236746D0|2015-02-26|
    BR112015004132A2|2017-07-04|
    MY179718A|2020-11-11|
    AU2013310947A1|2015-03-12|
    CL2015000455A1|2015-06-12|
    RU2015111241A|2016-10-20|
    CN104661696A|2015-05-27|
    US10265479B2|2019-04-23|
    TW201427738A|2014-07-16|
    US20150224266A1|2015-08-13|
    AR092276A1|2015-04-08|
    ZA201500299B|2015-12-23|
    EP3639872A1|2020-04-22|
    WO2014033195A1|2014-03-06|
    US9345841B2|2016-05-24|
    HK1208387A1|2016-03-04|
    AU2013310947B2|2017-04-13|
    TWI595903B|2017-08-21|
    SG11201500322TA|2015-02-27|
    JP6314139B2|2018-04-18|
    KR102166890B1|2020-10-16|
    RU2648866C2|2018-03-28|
    EP2890435A1|2015-07-08|
    CN104661696B|2018-04-20|
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    法律状态:
    2018-11-21| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2019-11-19| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2020-12-08| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2021-02-23| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 29/08/2013, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    EP12182564|2012-08-31|
    EP12182564.0|2012-08-31|
    US201261696496P| true| 2012-09-04|2012-09-04|
    US61/696,496|2012-09-04|
    PCT/EP2013/067860|WO2014033195A1|2012-08-31|2013-08-29|Drug delivery device|
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